![]() tick saliva invading skin (graphic from It's Science) |
from Yale News
A vaccine for humans against Lyme disease is still at least a few years in the future, but Yale University may have come one step closer to solving the problem.
A vaccine released over 25 years ago was withdrawn from the market in 2002. The withdrawal was not for medical reasons but was based on low sales, and negative perception about vaccinations in general.
Researchers at Yale are working on a completely different type of vaccine. This will not target one particular strain of the tick-borne disease, but the new approach quickly responds to the presence of tick saliva. The vaccine targets 19 different proteins found in several species of ticks.
The vaccine uses the same mRNA technology that was used to quickly develop COVID-19 vaccines, which is totally different chemistry from traditional vaccines which are usually weakened strains of the disease.
As an analogy, the vaccine makes a tick bite more like a mosquito bite. If you are vaccinated and then are bitten, you will notice redness and itching right away and can remove the tick before it can transmit diseases. Tick saliva normally supresses the human immune response allowing the pathogen time to infect the host, but the vaccine stops that supression.
Tests are being conducted on guinea pigs which can develop Lyme disease. Early animal trials showed 100% protection across six major Borrelia strains over a full tick season. Human trials are still in the future.
See mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent. Science Traslational Medicine has made the entire scientific paper available free of charge.
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